生物細胞鈉鈣離子交換通道，是以極快的速度讓鈣離子由細胞內與鈉離子交換至細胞外。本研究利用Poisson-Fermi之理論分析NCX(sodium calcium exchanger)之離子結合構造，使我們能夠以數學的方式探討鈉鈣離子在NCX的交換機制，並成功的解釋鈉鈣離子交換之實驗結果。

Biological sodium calcium ion exchange channel (NCX) removes calcium ions very rapidly from cell inside in exchange with sodium ions from outside. The Poisson-Fermi theory is used to analyze the binding potentials of NCX. It allows us to mathematically investigate the sodium-calcium ion exchange mechanism in NCX. Numerical results have been shown to agree with the experimental results of the sodium-calcium ion exchange.

1.緒論1
2.下載PDB和PQR1
2.1.PDB1
2.2.PQR2
3.建構鈉離子與鈣離子通道2
3.1.建構出NCX的蛋白質2
3.2.結合點的位置3
3.3.找出各切層的通道中心5
3.4.使用VMD修正座標與半徑6
3.5. 鈉離子與鈣離子通道7
4.鈣鈉離子交換機制8
4.1.NCX的變形結構8
4.2.計算結合點電位能9
4.3.離子交換機制流程12
5.結論14
附錄15
程式碼1：繪製NCX平面圖(MATLAB)15
程式碼2：繪製通道立體圖(MATLAB)21
程式碼3：計算結合點電位能(C++)23
程式碼4：建構NCX(C++)26
參考文獻30

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5. PDB2PQR Server http://nbcr-222.ucsd.edu/pdb2pqr_2.0.0/
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7. D.S. He, A Graphic Study of Biological Sodium Calcium Ion Exchange Channel, National Hsinchu University of Education (2015).
8. Visual Molecular Dynamics http://www.ks.uiuc.edu/Research/vmd/
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