本研究應用MIRD Schema之體內劑量計算評估方法，利用蒙地卡羅方法及擬人數值假體模擬驗證放射性核種與源、靶器官之各組合所建立比吸收分率和S值，並使用OLINDA/EXM及MCNPX二程式，分別針對核研所研發之「錸-188微脂體」新型放射性奈米藥物之診療患者進行體內劑量評估，透過轉換小鼠實驗數據獲得人體體內分佈近似資訊，並採用擬人數值假體進行人體體內分佈模擬及接受單次診療時之全身有效劑量計算。

本研究設計二程式三方法進行體內劑量評估，所設計之OLINDA/EXM Method 1乃輸入具時間依存性之藥物分佈進行計算，而所設計之OLINDA/EXM Method 2及MCNPX二方法乃輸入注射藥物1小時之分佈並採用錸-188物理半衰期取代藥物半衰期進行計算。由OLINDA/EXM Method 1所得體內劑量評估結果，每給予1MBq之「錸-188微脂體」新型藥物於診療患者將造成約0.164mSv之全身有效劑量。而由本研究近似之OLINDA/EXM Method 2和MCNPX所得體內劑量評估結果，每給予1MBq之「錸-188微脂體」新型藥物於診療患者將造成分別約為0.197mSv及0.180mSv之有效劑量。由OLINDA/EXM Method 1與OLINDA/EXM Method 2、OLINDA/EXM Method 1與MCNPX及OLINDA/EXM Method 2與MCNPX按照排列組合進行結果比較及數據分析所得結果差異分別約為17.0%、9.6%、8.5%。

The MIRD Schema had been investigated in this study, as the specific absorbed fraction (SAF) and the S-values were calculated by Monte Carlo method and the results were found to be consistent with literature values. Then, OLINDA/EXM and MCNPX were used to undergo internal dose assessment of the patient of 188Re-BMEDA-liposome. Through converting experimental mouse model data into anthropomorphic data, the effective dose was estimated.

Three methods of dual programs have been designed for the internal dose evaluation; they were OLINDA/EXM Method 1, OLINDA/EXM Method 2 and MCNPX method. OLINDA/EXM Method 1 was designed with time dependent pharmaceutical distribution input while OLINDA/EXM Method 2 and MCNPX methods were designed with pharmaceutical distribution at 1 hour after injection, and also the effective half-life was replaced by physical half-life. The result obtained by OLINDA/EXM Method 1 was about 0.164mSv per 1MBq administered. The results obtained by OLINDA/EXM Method 2 and MCNPX method indicated that each patient would receive an effective dose of 0.197mSv per 1MBq administered and 0.180mSv per 1MBq administered respectively. After comparing the results obtained in combinations of OLINDA/EXM Method 1 vs. OLINDA/EXM Method 2, OLINDA/EXM Method 1 vs. MCNPX and OLINDA/EXM Method 2 vs. MCNPX, the differences of values were 17.0%, 9.6%, 8.5% respectively.

摘要 iii
Abstract iv
致謝 v
目錄 vi
表目錄 viii
圖目錄 x
第一章　緒論 1
1.1　研究動機及目的 1
1.2　錸-188物理特性及錸-188微脂體藥物特性 3
1.3　核能研究所現階段研究 6
第二章　核醫體內劑量計算方法 9
2.1　核醫體內劑量理論 9
2.1.1　核醫診斷 9
2.1.2　核醫治療 10
2.1.3　核醫藥物 10
2.1.4　體內劑量評估 12
2.1.5　擬人數值假體應用 15
2.2　MIRD Schema 體內劑量計算評估方法 18
2.3　RADAR體內劑量評估系統 19
2.4　OLINDA/EXM 20
2.4.1　程式介面及使用說明 22
2.4.2　輸入參數 24
2.5　MCNPX 25
2.5.1　射源描述 26
2.5.2　幾何描述 28
2.5.3　材料描述 31
2.5.4　粒子歷程紀錄型式 32
2.5.5　比吸收分率與S值之計算 33
第三章　錸-188微脂體體內劑量評估結果 35
3.1　核研所錸-188微脂體藥物數據分析 35
3.1.1　藥物半衰期及生物體分佈計算 35
3.1.2　有效劑量數值估算 41
3.2　OLINDA/EXM Method 1與Method 2之計算結果比較 44
3.3　MCNPX與OLINDA/EXM計算結果比較 48
3.3.1　比吸收分率 48
3.3.2　S值 56
3.3.3　錸-188單一源器官與全身均勻分佈有效劑量 66
3.3.4　錸-188微脂體全身藥物分佈有效劑量 72
3.4　核醫診療患者全身有效劑量評估 76
第四章　結論及未來研究 79
參考文獻 82
附錄 86

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