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1. Minna, J.D., J.A. Roth, and A.F. Gazdar, Focus on lung cancer. Cancer Cell, 2002. 1(1): p. 49-52. 2. Siegel, R., D. Naishadham, and A. Jemal, Cancer statistics, 2013. CA Cancer J Clin, 2013. 63(1): p. 11-30. 3. Ettinger, D.S., et al., Non-small cell lung cancer. J Natl Compr Canc Netw, 2012. 10(10): p. 1236-71. 4. Pacheco-Pinedo, E.C., et al., Wnt/beta-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium. J Clin Invest, 2011. 121(5): p. 1935-45. 5. Lemjabbar-Alaoui, H., et al., Wnt and Hedgehog are critical mediators of cigarette smoke-induced lung cancer. PLoS One, 2006. 1: p. e93. 6. Ohgaki, H., et al., APC mutations are infrequent but present in human lung cancer. Cancer Lett, 2004. 207(2): p. 197-203. 7. Mazieres, J., et al., Wnt signaling in lung cancer. Cancer Lett, 2005. 222(1): p. 1-10. 8. Uematsu, K., et al., Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression. Oncogene, 2003. 22(46): p. 7218-21. 9. Logan, C.Y. and R. Nusse, The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol, 2004. 20: p. 781-810. 10. Bhanot, P., et al., A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature, 1996. 382(6588): p. 225-30. 11. Wehrli, M., et al., arrow encodes an LDL-receptor-related protein essential for Wingless signalling. Nature, 2000. 407(6803): p. 527-30. 12. Zeng, X., et al., A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature, 2005. 438(7069): p. 873-7. 13. Mao, J., et al., Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell, 2001. 7(4): p. 801-9. 14. Wong, H.C., et al., Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol Cell, 2003. 12(5): p. 1251-60. 15. He, X., et al., LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way. Development, 2004. 131(8): p. 1663-77. 16. Li, V.S., et al., Wnt signaling through inhibition of beta-catenin degradation in an intact Axin1 complex. Cell, 2012. 149(6): p. 1245-56. 17. Schuijers, J., et al., Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF. EMBO J, 2014. 33(2): p. 146-56. 18. Kawano, Y. and R. Kypta, Secreted antagonists of the Wnt signalling pathway. J Cell Sci, 2003. 116(Pt 13): p. 2627-34. 19. Bienz, M. and H. Clevers, Linking colorectal cancer to Wnt signaling. Cell, 2000. 103(2): p. 311-20. 20. Terry, K., et al., Sfrp-1 and sfrp-2 are expressed in overlapping and distinct domains during chick development. Mech Dev, 2000. 97(1-2): p. 177-82. 21. Leimeister, C., A. Bach, and M. Gessler, Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family. Mech Dev, 1998. 75(1-2): p. 29-42. 22. Rattner, A., et al., A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc Natl Acad Sci U S A, 1997. 94(7): p. 2859-63. 23. Jones, S.E. and C. Jomary, Secreted Frizzled-related proteins: searching for relationships and patterns. Bioessays, 2002. 24(9): p. 811-20. 24. Bafico, A., et al., Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling. J Biol Chem, 1999. 274(23): p. 16180-7. 25. Fukui, T., et al., Transcriptional silencing of secreted frizzled related protein 1 (SFRP 1) by promoter hypermethylation in non-small-cell lung cancer. Oncogene, 2005. 24(41): p. 6323-7. 26. Lo, P.K., et al., Epigenetic suppression of secreted frizzled related protein 1 (SFRP1) expression in human breast cancer. Cancer Biol Ther, 2006. 5(3): p. 281-6. 27. Shih, Y.L., et al., Promoter methylation of the secreted frizzled-related protein 1 gene SFRP1 is frequent in hepatocellular carcinoma. Cancer, 2006. 107(3): p. 579-90. 28. Saini, S., et al., Functional significance of secreted Frizzled-related protein 1 in metastatic renal cell carcinomas. Cancer Res, 2009. 69(17): p. 6815-22. 29. Fukuhara, K., et al., Secreted frizzled related protein 1 is overexpressed in uterine leiomyomas, associated with a high estrogenic environment and unrelated to proliferative activity. J Clin Endocrinol Metab, 2002. 87(4): p. 1729-36. 30. Uren, A., et al., Secreted frizzled-related protein-1 binds directly to Wingless and is a biphasic modulator of Wnt signaling. J Biol Chem, 2000. 275(6): p. 4374-82. 31. Cheng, Y.Y., et al., Frequent epigenetic inactivation of secreted frizzled-related protein 2 (SFRP2) by promoter methylation in human gastric cancer. Br J Cancer, 2007. 97(7): p. 895-901. 32. Lin, Y.W., et al., Promoter methylation of SFRP3 is frequent in hepatocellular carcinoma. Dis Markers, 2014. 2014: p. 351863. 33. He, B., et al., Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells. Cancer Res, 2005. 65(3): p. 743-8. 34. Veeck, J., et al., Epigenetic inactivation of the secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosis. Carcinogenesis, 2008. 29(5): p. 991-8. 35. Yamamura, S., et al., Oncogenic functions of secreted Frizzled-related protein 2 in human renal cancer. Mol Cancer Ther, 2010. 9(6): p. 1680-7. 36. Clevers, H., The cancer stem cell: premises, promises and challenges. Nat Med, 2011. 17(3): p. 313-9. 37. Lapidot, T., et al., A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature, 1994. 367(6464): p. 645-8. 38. Bonnet, D. and J.E. Dick, Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med, 1997. 3(7): p. 730-7. 39. Al-Hajj, M., et al., Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A, 2003. 100(7): p. 3983-8. 40. Visvader, J.E. and G.J. Lindeman, Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer, 2008. 8(10): p. 755-68. 41. Reya, T., et al., Stem cells, cancer, and cancer stem cells. Nature, 2001. 414(6859): p. 105-11. 42. Dean, M., T. Fojo, and S. Bates, Tumour stem cells and drug resistance. Nat Rev Cancer, 2005. 5(4): p. 275-84. 43. Reya, T. and H. Clevers, Wnt signalling in stem cells and cancer. Nature, 2005. 434(7035): p. 843-50. 44. Lustig, B. and J. Behrens, The Wnt signaling pathway and its role in tumor development. J Cancer Res Clin Oncol, 2003. 129(4): p. 199-221. 45. Graham, T.A., et al., Crystal structure of a beta-catenin/Tcf complex. Cell, 2000. 103(6): p. 885-96. 46. Porfiri, E., et al., Induction of a beta-catenin-LEF-1 complex by wnt-1 and transforming mutants of beta-catenin. Oncogene, 1997. 15(23): p. 2833-9. 47. Takahashi-Yanaga, F. and M. Kahn, Targeting Wnt signaling: can we safely eradicate cancer stem cells? Clin Cancer Res, 2010. 16(12): p. 3153-62. 48. Cao, L., et al., Sphere-forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines. BMC Gastroenterol, 2011. 11: p. 71. 49. Anastas, J.N. and R.T. Moon, WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer, 2013. 13(1): p. 11-26. 50. Ying, Y. and Q. Tao, Epigenetic disruption of the WNT/beta-catenin signaling pathway in human cancers. Epigenetics, 2009. 4(5): p. 307-12. 51. Suzuki, H., et al., Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet, 2004. 36(4): p. 417-22. 52. Niehrs, C. and S.P. Acebron, Wnt signaling: multivesicular bodies hold GSK3 captive. Cell, 2010. 143(7): p. 1044-6. 53. McCartney, B.M. and I.S. Nathke, Cell regulation by the Apc protein Apc as master regulator of epithelia. Curr Opin Cell Biol, 2008. 20(2): p. 186-93. 54. Xing, Y., et al., Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function. Mol Cell, 2004. 15(4): p. 523-33. 55. Valenta, T., G. Hausmann, and K. Basler, The many faces and functions of beta-catenin. EMBO J, 2012. 31(12): p. 2714-36. 56. Tago, K., et al., Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. Genes Dev, 2000. 14(14): p. 1741-9. 57. Singh, A.M., et al., Chibby, an antagonist of the Wnt/beta-catenin pathway, facilitates cardiomyocyte differentiation of murine embryonic stem cells. Circulation, 2007. 115(5): p. 617-26. 58. Wawrzak, D., et al., Wnt3a binds to several sFRPs in the nanomolar range. Biochem Biophys Res Commun, 2007. 357(4): p. 1119-23. 59. Gan, X.Q., et al., Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction. J Cell Biol, 2008. 180(6): p. 1087-100. 60. Hirota, M., et al., Smad2 functions as a co-activator of canonical Wnt/beta-catenin signaling pathway independent of Smad4 through histone acetyltransferase activity of p300. Cell Signal, 2008. 20(9): p. 1632-41. 61. Li, C., et al., The roles of Notch3 on the cell proliferation and apoptosis induced by CHIR99021 in NSCLC cell lines: a functional link between Wnt and Notch signaling pathways. PLoS One, 2013. 8(12): p. e84659. 62. Yu, Z., et al., Cancer stem cells. Int J Biochem Cell Biol, 2012. 44(12): p. 2144-51. 63. Holland, J.D., et al., Wnt signaling in stem and cancer stem cells. Curr Opin Cell Biol, 2013. 25(2): p. 254-64. 64. Kanwar, S.S., et al., The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres. Mol Cancer, 2010. 9: p. 212. 65. Sandberg, C.J., et al., Comparison of glioma stem cells to neural stem cells from the adult human brain identifies dysregulated Wnt- signaling and a fingerprint associated with clinical outcome. Exp Cell Res, 2013. 319(14): p. 2230-43. 66. Bisson, I. and D.M. Prowse, WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics. Cell Res, 2009. 19(6): p. 683-97.
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