Poly(glycerol sebacate) (PGS)為新一代生物可降解高分子材料並可以應用於軟組織修復。由於具有高生物相容性及線性降解的的特性，有關PGS之研究在最近幾年內受到全世界的注目。但為了拓展其應用領域並提升性質(例如: 機械性質、降解速率以及生物相容性)，不同的高分子改質應用於PGS上。
本論文提出一個嶄新並可用於軟組織修復的生物可降解高分子共聚物藉由結合Poly(glycerol sebacate) 和 Poly(vinyl alcohol)來形成poly (glycerol sebacate-vinyl alcohol)(PGS-PVA)並且包含不同的變因對於PGS-PVA的影響。變因可以分為兩大部分，第一部分是關於Poly(vinyl alcohol)之因素，包括分子量，水解度，以及不同的重量比例，第二部分是關於交聯過程之因素，包括交聯溫度以及時間。

PGS-PVA之高分子膜呈現高透明度並具有可曲折之特性。不同的機械性質可藉由變化相關變因來達成，其楊氏係數介於1到4.97 MPa之間、最大拉伸強度在0.346和0.93 MPa之間、以及其破斷拉伸率為17.78到41.18%。經由楊氏係數結果中發現，交聯時間和PVA在系統中的重量比例跟PGS-PVA之楊氏係數為正相關。
在材料結構方面，PGS-PVA之結構會隨著不同的重量比例之PVA而變化。當 PVA之添加量為最高時，PGS-PVA會從半結晶相變成非結晶相。在經過生物降解56天後發現PGS-PVA比PGS顯示較慢的降解速率(degradation)以及較高的吸水能力(swelling index)(PGS-PVA: degradation:15~30%/ swelling index:15%~65%，PGS: degradation:87%/ swelling index:8% )並其降解速率及吸水程度會隨著交聯時間增加而減少。
再者經過接觸角測試後發現PGS-PVA顯示出較高親水程度並和系統中之PVA重量比例成正相關。在PGS-PVA生物相容性方面，藉由細胞螢光圖可判定PGS-PVA具有高細胞存活率並且良好的細胞貼附能力。
本研究之生物可降解共聚高分子為結合親水性高分子，以及疏水性之高分子之所成，並希望此生物可降解共聚高分子可以應用於醫療器材以及組織工程。

關鍵字: Poly (glycerol sebacate), Poly(vinyl alcohol)、生物可降解高分子

Poly (glycerol sebacate) is a novel biodegradable polymer for soft tissue regeneration and has been well studied for its good biocompatibility and linear degradation rate. Although PGS is considered a good material for tissue engineering, the need for modifications on PGS is necessary to improve the biocompatibility, mechanical strength, and degradation properties and further extend its applications in medical devices. Here, we present a novel biodegradable co-polymer, poly (glycerol sebacate-vinyl alcohol) (PGS-PVA) by combining Poly (glycerol sebacate) (PGS) and Poly (vinyl alcohol) (PVA) in order to provide a suitable material for soft tissue medical applications. Several variables are thoroughly investigated to understand their influence to PGS-PVA performance. The variables can be divided into two categories: one is PVA related (including molecular weight, degree of hydrolyzation and the quantity of PVA added) and the other is curing conditions (includes curing temperature and curing time). High degree of transparency and flexibility are shown in all PGS-PVA films. Mechanical properties of PGS-PVA are characterized through stress-strain test. Young modulus (1.11~4.79 MPa ), ultimate tensile strength (0.346~0.93 MPa ) and strain at failure(17.78~41.8% ) are shown in PGS-PVA films with different mixing ratio. The mechanical properties of PGS-PVA are shown to be positive correlation with curing time and quantity of added PVA. The structure of PGS-PVA is influenced with the addition of PVA through differential scanning calorimeter scanning. The structure of PGS-PVA with highest PVA addition is amorphous state in contrast to the semi-crystalline state presented in pure PGS. Degradation of PGS-PVA are characterized with lipase catalyst and show less degradability (15%~30%) and higher swelling indices (15%~65%) when comparing to pure PGS (87% in degradation and 8% in swelling index) within 56 days of degradation. The degradation rates of PGS-PVA are found to be decreased with the increase of curing time.
Hydrophilic surface are observed in PGS-PVA and degree of hydrophilicity in PGS-PVA are positive correlation with the quantity of added PVA.
Good cell viability and cell adhesion are confirmed by fluorescent images. This work is expected to bring forth a new hybrid biodegradable/water-soluble co-polymer, providing a valuable new choice for medical device and tissue engineering.
Keyword: Poly (glycerol sebacate), Poly(vinyl alcohol) and biodegradable polymer

Abstract
中文摘要
Table of Content
List of Tables
List of Figure
Chapter 1 Literature Review
1.1 Introduction to Biomaterial
1.1.1Introduction to Biocompatibility
1.1.2 Different Material Used in Medical Devices Fabrication
1.1.3 Global Use Polymeric Material in Medical Devices
1.2. Introduction to Biodegradable Polymer
1.2.1 Background of Biodegradable Polymer
1.2.2 Introduction to Biodegradation
1.2.3 Mechanisms of Biodegradation
1.2.4 Introduction to Common Biodegradable Polymers
1.3 Introduction to Poly (glycerol sebacate)
1.3.1 Co-Polymers and Blends Derived from PGS
1.4 Introduction to Poly (Vinyl Alcohol)
1.4.1 Co-Polymers and Blends Derived from PVA
1.5 Motivation and Objective of this Research
Chapter 2 Experimental Design
2.1 Structure of Experimental Design
2.2 Materials and Equipment
2.3 Synthesis of PGS-PVA pre-Polymer and Film
2.4 Characterization
Chapter 3 Result and Discussion
3.1 Result and Discussion of PGS-PVA and PGS pre-polymer
3.1.1 Chemical Characterization
3.1.2 Gel Permeation Chromatography Characterization
3.2 Result and Discussion of PGS-PVA Films and PGS Films
3.2.1 Thermal properties
3.2.2 Mechanical properties
3.2.3 Structure properties
3.2.4 In Vitro Biodegradation
3.2.5 In Vitro Biocompatibility
Chapter 4 Conclusion
Chapter 5 Reference

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