現代世界的電力照明光源，尤其是不當的夜間光照，會造成生理節奏的紊亂並增加罹患乳癌的機率，乳癌已成為全球女性癌症死亡的首要原因，其關鍵因素為夜間光照對「褪黑激素（Melatonin, MLT），又稱為抑制腫瘤生長激素」分泌的抑制；然而，目前多數研究是以單色光光源進行MLT抑制的實驗，因此，本研究使用實驗室所擁有的「用以量測褪黑激素抑制之裝置」專利，透過該專利之MLT抑制效率作用光譜，可精確地預測一般照明或顯示器等環境光源對人體MLT造成多少程度的抑制。根據結果，一般照明中，白光螢光燈管和白光發光二極體對MLT抑制程度最嚴重，於100勒克斯下分别造成64%和63% MLT的抑制；相對而言，蠟燭與類燭光有機發光二極體僅分別造成46%和33% MLT的抑制。顯示器而言，適當觀看距離下，大尺寸電視、電腦顯示器、筆記型電腦、平板與手機仍大幅對MLT造成45%至59%的抑制。此外，捕蚊燈更能產生達飽和70% MLT抑制，紅外線加熱器亦可導致25% MLT抑制。此研究揭示各式照明與顯示用光源中的色溫、照度、距離與藍光成分多寡如何抑制MLT分泌。

Over exposure of electric light at night causes circadian disruption and increases the risk of breast cancer, the global leading cause of women's cancer death. One major factor of these is the suppression of light on the secretion of melatonin (MLT), an oncostatic hormone generated by pineal gland during the dark night. The suppression is to vary with the variation of wavelength, dosage, and duration according to previous studies, mostly based on monochromatic lights. The practical ambient lights are however polychromatic, either from the general lighting or display, and there lacks an action spectrum to quantify how the ambient lights affect the suppression of MLT. In this study, we present an action spectrum of MLT suppression that covers the effects of emission over the entire visible range. We found in lighting that white fluorescent tubes and white LED lamps have the most severe impact; they respectively show an around 64%suppression at100 lx, a typical illuminance at home. In contrast, the suppression is 46% and 33% for candles and candlelight-style OLEDs. In display, large size TVs show a suppression around53% at a 2m watching distance, 56% for general PC monitors at 60cm, and 55% for laptops at 40cm. The suppression is around57% by viewing mobile phones at 20 cm or tablets at 30 cm. Surprisingly, bug zapper causes a saturated 70% suppression and IR-based heater also causes 25% suppression. Our results demonstrate how color-temperature, blue and violet lights, illuminance, and viewing distance sensitively affect the suppression of MLT, and healthy light can hence be designed and proper safe measures be taken to safeguard human health.

摘要II
英文摘要III
致謝V
目錄VIII
表目錄X
圖目錄XI
壹、緒論 1
貳、文獻回顧3
2-1 褪黑激素的重要性3
2-2 光對褪黑激素的影響10
2-3 光與視覺的關係20
2-4 生活周遭的光源26
2-4-1 照明光源27
2-4-2 顯示器31
參、實驗方法33
3-1 褪黑激素抑制理論基礎33
3-1-1 褪黑激素抑制作用光譜（光子33
3-1-2 褪黑激素抑制作用光譜（流明34
3-1-3 曝照量與褪黑激素抑制的關聯36
3-2 光源光譜之量測38
3-3 光源照度之量測39
肆、結果與討論42
4-1 單色光對褪黑激素分泌的影響42
4-1-1 波長對褪黑激素抑制之能力（光子／流明）42
4-1-2亮度（照度）對褪黑激素的影響45
4-2 各式光源光譜與色溫50
4-3 不同距離之各式光源亮度（照度）54
4-4 生活周遭光源對褪黑激素分泌的影響59
4-4-1 檯燈62
4-4-2 電視64
4-4-3 電腦／筆記型電腦66
4-4-4 平板／手機69
4-4-5 其他光源70
伍、結論74
陸、參考資料77
附錄、個人著作目錄94

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