因為高血壓疾病對於人體後續造成的危害，以及其不易被發現的特性，連續偵測血壓對現代人的疾病預防和診斷具有重要的臨床價值。然而，傳統的血壓測量儀器由於其舒適度差、攜帶性差且無法進行連續偵測的問題，研發出一種可連續偵測且改善傳統血壓計問題的設備是必要的，因此本文提出了一個基於FBG的連續血壓量測系統。
本研究利用雙FBG的低成本架構，透過量測光功率的改變，而取得人體的脈搏波形。將波形中的脈波傳遞時間(PTT)數據提取出，透過PTT對袖帶式電子血壓計所量測到的參考血壓做擬合，得出估算血壓的模型，此估計模型是利用19名受試者的數據去建立的，並且透過兩名高血壓受試者的數據對血壓估計模型進行調整，另外還對8位受試者進行臨床實驗，其中包含一位高血壓患者，以測試本實驗架構的準確度，最後再分別加入Pt和Dt兩個參數進行微調，進一步降低擬合結果的誤差。結果顯示，與袖帶式電子血壓計相比，量測的收縮壓(SBP)及舒張壓(DBP)其最終誤差分別為2.20mmHg和2.10mmHg，這樣的誤差在我國經濟部標準檢驗局所規定之無創血壓測量設備的臨床實驗規範誤差內，表明本實驗架構具有良好的準確性。

The continuous monitoring of blood pressure is of significant clinical value for disease prevention and diagnosis, considering the potential damage, such as cardiovascular diseases, caused by hypertension and its often undetectable nature. However, traditional blood pressure measurement devices suffer from discomfort, poor portability, and the inability to provide continuous monitoring. Therefore, this study proposes a continuous blood pressure measurement system based on Fiber Bragg Grating (FBG) technology.

In this research, a low-cost dual-FBG architecture is employed to capture the pulse waveform of the human body by measuring changes in optical power. The Pulse Transit Time (PTT) , ejection time and diastolic time, extracted from the waveform are used in a blood pressure estimation model by fitting it to the reference blood pressure obtained from an electronic sphygmomanometer. The estimation model is developed using data from 19 subjects, with adjustments made using data from two hypertensive patients. Clinical experiments were conducted on eight subjects, including one with hypertension, to assess the accuracy of the proposed framework.

The results demonstrate that compared to the electronic sphygmomanometer, the measured Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) exhibit errors of 2.20 mmHg and 2.10 mmHg, respectively. These errors fall within the clinical experiment specifications for non-invasive blood pressure measurement devices, as prescribed by the Bureau of Standards, Metrology, and Inspection of the Ministry of Economic Affairs in our country, indicating the high accuracy of the proposed framework.

第一章 緒論 1
1.1 前言 1
1.2 研究動機與目標 3
1.3 文獻回顧 4
1.4 論文架構 6
第二章 基本原理 7
2.1 光纖原理 7
2.1.1 光纖基本原理 7
2.1.2 布拉格光纖光柵感測器 9
2.1.3 光纖耦合器 12
2.1.4 摻鉺光纖放大器 12
2.2 脈搏波形原理 15
2.2.1 脈搏波形的介紹 15
2.2.2 脈波時域分析法 16
2.2.3 脈波傳遞時間 16
第三章 實驗架構 18
3.1 光路架構 18
3.2 矽膠模架構 21
3.2.1 矽膠模樹脂 21
3.2.2 在矽膠膜中設置FBG 23
3.2.3 量取脈搏波形之固定架構 24
3.3 脈搏波形數據擷取 26
3.4 脈搏波形訊號處理 28
3.5 血壓估計模型 30
第四章 實驗結果與討論 32
4.1 實驗步驟 32
4.2 脈搏波形與數據結果 32
4.2.1 受試者數據結果 33
4.2.2 結果整理 53
4.2.3 血壓估計模型比較 54
4.3 高血壓案例實驗 57
4.3.1 高血壓受試者數據結果 57
4.3.2 高血壓受試者數據結果分析 59
4.3.3 血壓估計模型調整 59
4.4 血壓估計模型驗證 61
4.4.1 初次驗證結果 61
4.4.2 血壓估計模型微調 63
4.5 參考文獻數據結果比較 66
第五章 實驗總結與未來展望 69
參考文獻 71

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