硼清華水池式反應器(Tsing Hua Open-pool Reactor, THOR)自2010年開始進行BNCT迄今已進行200次以上治療，在每次病人接受照射前都需要由治療計畫軟體計算出最適當的照射角度以及病人體內劑量分佈，為確保計算無誤使用的治療計畫軟體必須先經過驗證。
對於BNCT治療計畫之驗證，現行的方法為在均質的水假體中測量中子通量，再與治療計畫計算結果相比較。但以上的方法缺少在區域域的中子通量測量，而且人體構成並非均質的，這部分的計算才是對治療計畫的考驗。本研究設計模擬人體頭部的異質假體，由此建立基準測試提供射源項與治療計畫驗證，考題包含測試不同程度的異質性、射源中心以及邊緣的計算準確度，為治療計畫提供信心度。
研究中參考Snyder Head Phantom製作出用於實際測量的異質假體，並在假體中增加空腔以及腫瘤。驗證包含三個部分：薄片活化測量假體、模擬計算理論值、治療計畫計算值，可視情形採用其中兩項或三項用於驗證射源項或治療計畫。
以此假體驗證治療計畫Insight顯示計算異質區域時準確度下降，證實異質假體可以提供治療計畫與均質假體不同的考驗，以及幫助未來治療時提供更高的心信度。

Tsing Hua Open-pool Reactor (THOR) has been treating head & neck cancer patients since 2010, and to date already over 200 cases. Before each treatment section, the optimal irradiation angle and parameters should be resolved and further calculate dose distribution by the treatment planning system. A new treatment planning system, Insight, was developed by our lab which is going to apply in clinical in the future, to guarantee that the calculation done by it is correct, verification work should be done first.
For the verification of BNCT treatment plan, the current fashions are to measure in homogeneous phantoms, and then compare the results with the calculated results of the treatment plan. However, the above methods lack profiles in different materials. This study aims at developing a heterogeneous phantom for BNCT verification and providing confidence for future treatment.
The reference of the heterogeneous phantom was Snyder Head Phantom, extra air-cavity and tumor structure were added to increase variety. The workflow of verification is (1) neutron activation analysis in the phantom (2) analytical calculation by MCNP (3) treatment planning system calculation, and finally compares the difference between the three results.
The validation results showed that the accuracy of the calculation of the heterogeneous area decreased, confirming that the heterogeneous phantom can provide more tests for the treatment plan than the homogeneous phantom, and help provide higher confidence in future treatments.

摘要..............i
Abstract..............ii
致謝..............iii
目錄.............. iv
表目錄..............vii
圖目錄..............viii
第一章 緒論..............1
1.1 硼中子捕獲治療..............1
1.2 文獻回顧..............2
1.2.1 國外治療計畫驗證..............2
1.2.2 國內治療計畫驗證..............3
1.2.3 驗證假體製作..............5
1.3 研究動機..............6
第二章 THOR-BNCT..............7
2.1 設施簡介..............7
2.2 例行射束QC/QA..............8
2.2.1 中子即時監測系統..............8
2.2.2 雙游離腔測量..............9
2.2.3 雙薄片活化測量..............9
第三章 研究材料與工具..............11
3.1 中子活化分析..............11
3.1.1 活化反應率..............12
3.1.2 高純鍺偵檢器與測量設備..............14
3.2 蒙地卡羅方法計算反應率..............16
3.3 Y09射源項..............18
3.4 治療計畫INSIGHT..............18
3.4.1 Voxels介面操作..............19
3.4.2 Source介面操作..............19
3.4.3 Dose介面操作..............20
3.5 假體設計以及製作..............22
3.5.1 均質假體..............22
3.5.2 異質假體..............23
3.5.2.1 Snyder Head Phantom..............23
3.5.2.2 假體設計..............24
3.5.2.2.1 異質假體幾何..............24
3.5.2.2.2 異質假體材料..............25
3.5.2.2.3 異質假體製作..............26
3.5.3 異質假體評估..............28
第四章 驗證流程與方法..............31
4.1 均質假體驗證流程..............31
4.2 異質假體驗證流程..............31
4.2.1 代號定義與驗證案例..............32
4.2.1.1 照射方向..............32
4.2.1.2 測量位置..............32
4.2.1.3 射束位置..............33
4.2.1.4 驗證案例..............34
4.3 金線反應率測量..............36
4.4 金線反應率模擬..............37
4.4.1 磷酸鈣粉密度..............37
4.5 治療計畫金線反應率計算..............38
4.5.1 體素尺寸..............40
第五章 測量與計算結果比較..............42
5.1 模擬計算：均質與異質假體比較..............42
5.2 測量：均質假體結果..............42
5.3 測量：異質假體結果..............56
5.3.1 案例一：前向－中心照射..............56
5.3.2 案例二：前向－離心照射..............57
5.3.3 案例三：背向－中心照射..............58
5.3.4 案例四：背向－離心照射..............59
5.4 分析比較..............83
5.4.1 測量vs模擬..............83
5.4.1.1 立方體與圓柱體均勻假體比較..............83
5.4.1.2 均質與異質假體的計算比較..............83
5.4.1.3 異質假體中區域一與區域二比較..............85
5.4.2 模擬vs治療計畫..............85
5.4.2.1 案例一：前向－中心照射..............86
5.4.2.2 案例二：前向－離心照射..............86
5.4.2.3 案例三：背向－中心照射..............88
5.4.2.4 案例四：背向－離心照射..............88
5.4.3 測量vs治療計畫..............90
第六章 結論與未來工作..............91
6.1 驗證結果..............91
6.2 未來工作..............91
參考文獻..............93
附錄I 異質假體驗證案例規格..............95
附錄II異質假體驗證案例結果..............149

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