與傳統化工廠相比，在微反應器中進行化學合成具有許多優點，且學術界和工業界都已進行了許多試驗。在我們團隊的設計中，玻璃微流控芯片以串聯實現靈活的設計可能性，並以並聯解決微反應器固有的低通量問題。在微反應器中，進料流量控制是必不可少的，因為成功的化學反應依賴於精確的濃度控制。在流量傳感器的幫助下，我們注意到不同尺寸的微通道/管道對注射泵上相同的流量設置變化的響應是不同的。我們還注意到，來自注射泵步進運動的高頻雜訊在不同尺寸的微通道/管道中分別受到不同程度的阻尼。為了了解不同微流控通道/管材尺寸所帶來的不同響應模式，在本研究中，將量化不同管材尺寸/設置的微流控通道/管材對流速設置變化和高頻信號阻尼性能的響應，基於流體阻力和微流道體積的假設將得到驗證。

Chemical synthesizing in microreactors has many merits over conventional chemical plants, and many trials have been done in both the academic world and industry. In our team’s design, glass microfluidic chips are connected serially to realize flexible design, and parallelly to solve the intrinsic low-through problem of microreactors. In microreactors, feed flow control is essential because successful chemical reactions rely on precise concentration control. With the aid of flow sensors, we noticed that the response to the same flow rate setting change on syringe pumps is different among microchannels/tubing of different dimensions. We also noticed that the high-frequency signals from the step motion of syringe pumps are damped differently in microchannels/tubing of different dimensions. In order to understand the different response patterns of different microfluidic channel/tubing dimensions, in this study, the response to flow rate setting changes and high-frequency signal damping performance in microfluidic channel/tubing of different tubing dimensions/settings will be quantitated, and hypotheses based on fluidic resistance and tubing volume will be validated.

Abstract i
LIST OF FIGURES i
LIST OF TABLES iii
NOMENCLATURE iv
CHAPTER I. INTRODUCTION - 1 -
1.1 Microfluidics Basics - 1 -
1.1.1 Brief History - 1 -
1.1.2 Physical Properties in Micro-space - 2 -
1.1.3 Methodology: MUO and CFCP - 4 -
1.1.4 Chemical Synthesis in Micro-Space - 5 -
1.2 Microfluidic Multidevice System - 8 -
1.2.1 Parameters to be controlled - 8 -
1.2.2 Serial and Parallel connection - 8 -
1.2.3 Flow Control Method - 9 -
1.3 Damping in Hydraulic Systems - 13 -
1.3.1 Definition of Damping - 13 -
1.3.2 Damping Mechanism in a Mobile Hydraulic System - 14 -
1.4 Motivation and Goals - 15 -
1.4.1 Clarification of Phenomena in Flow response - 15 -
1.4.2 Development of Flow Control Method - 15 -
CHAPTER II. MULTIDEVICE SYSTEM EXPERIMENT - 16 -
2.1 Design of Multidevice System (Based on chemical reaction) - 16 -
2.2 Configuration of the 4-by-1 system - 17 -
2.3 Evaluation of Flow Control - 19 -
2.3.1 Signal Propagation and Attenuation - 21 -
2.3.2 Connection Sequence Validation - 22 -
2.3.3 Results - 23 -
2.4 Evaluation of Fluidic Resistance and Volume - 34 -
2.4.1 Fluidic Resistance and Response Time (Tubing only) - 35 -
2.4.2 Fluidic Resistance and Response Time (Connected to One Chip) - 35 -
2.4.3 Fluidic Resistance and Response Time (Connected to the 4-by-1 system) - 36 -
2.4.4 Volume and Stabilization - 37 -
2.4.5 Volume and Response Time - 38 -
2.4.6 Results - 39 -
CHAPTER III. DISCUSSION - 48 -
3.1 Evaluation of Damping Phenomena - 48 -
3.1.1 Fluidic Resistance Damping - 48 -
3.1.2 Volume Damping - 50 -
3.1.3 Other Factors of Damping - 52 -
3.1.4 Proposal for Damping Phenomena Model - 53 -
3.1.5 Proposal for flow control system - 57 -
CHAPTER IV. CONCLUSION - 58 -
References - 59 -

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