本研究利用光纖布拉格光柵能夠隨應力應變的特性來量測脈搏，並且針對《難經》中的寸關尺分侯臟腑之說進行驗證。中醫脈診主張寸口脈法，此種方法有方便隨時量測、脈動較大等等優點，因此中醫皆利用三指進行寸口脈診，但是正因為診斷的結果是靠手指做感覺，難免產生主觀上的誤解，因此期望能利用本研究的架構來實現客觀量化中醫寸口脈診。
本文將三個不同布拉格波長的光柵依照寸關尺的位置用矽膠膜黏合在一起，矽膠膜一方面能夠增加脈動造成的應力，一方面能夠保護光纖，因此整個架構皆由矽膠膜包裹，減少光纖脆弱易斷的缺點，並增加其實用性。將製備好的架構平貼在受測者的寸關尺上並且用木工L型夾提供應力來模擬中醫脈診，得到的資料由I-MON USB擷取，並且利用MATLAB做快速傅立葉轉換得到c0〜c5六個諧波，再依照其相對數值比例大小進行身體評估。本文對異位性皮膚炎患者及心臟疾病患者和正常人的差異做量測，並驗證系統的可能性。

Fiber Bragg gratings can be used to measure the pulse waveforms in accordance with the stress and strain applied on radial artery, and verify against the theory of " cun,guan and chi " in "Nanjing". TCM（traditional chinese medicine）pulse diagnosis advocates radial artery diagnosis, because it has the advantages of convenient measurement,large pulse, etc. Therefore, traditional Chinese medicine uses three fingers for radial artery diagnosis, but the diagnosis results are based on individual finger feeling, which inevitably leads to subjective misunderstanding. Therefore, we expect to use the framework of this study to achieve the quantification of radial artery diagnosis in traditional Chinese medicine.
In this paper, three gratings with different Bragg wavelengths are bonded together within a silicone mold according to the positions of the cun,guan and chi. The silicone mold can increase the stress caused by the pulsation and protect the optical fiber on the other hand. Therefore, the entire structure is wrapped by the silicone mold, reducing the possibility of breaking of fragile fibers and increasing its usefulness. The prepared framework was firmly attached to the radial artery at the positions of cun,guan and chi,and a woodworking L-shaped clip was used to provide stress to simulate the pulse diagnosis of traditional Chinese medicine. The pulse were acquired with an I-MON USB, and Fast Fourier Transform of the pulse waveforms were taken to obtain six spectral amplitudes of harmonics, i.e. , c0 to c5, and then physical assessment was made according to relative numerical scale of their harmonics . In this paper, the difference between the c3 amplitude of a patients with atopic dermatitis and that of a normal person was measured. Moreover, the difference between c0 of that of a patients with heart disease and a normal person was measured ,and the reliability of the system was verified.

第一章 緒論 14
1.1 前言 14
1.2 研究動機與目標 16
1.3 文獻回顧 17
1.3.1 國內文獻回顧 17
1.3.2 國外文獻回顧 18
1.4 論文架構 19
第二章 基本原理 20
2.1 光纖原理 20
2.1.1 光纖基本原理 20
2.1.2 布拉格光纖光柵感測器 21
2.1.3 光纖耦合器 24
2.1.4 摻鉺光纖 25
2.2 脈波原理 27
2.2.1 脈波圖的定義 27
2.2.2 寸、關、尺對應各部位定義 28
2.2.3 脈波時域分析法 31
2.2.4 脈波頻域分析法 34
2.2.5 快速傅立葉轉換 36
第三章 實驗架構 37
3.1 光路架構 37
3.2 矽膠膜架構 40
3.2.1 矽膠膜樹脂 40
3.2.2 布拉格光纖設置 42
3.2.3 灌漿步驟與成品 44
3.3 施力架構 46
3.4 頻譜資料擷取 49
3.5 脈波訊號分析 52
第四章 實驗結果與討論 56
4.1 實驗步驟 56
4.2 脈波實驗 58
4.2.1 浮中沉定義 58
4.2.2 正常人與異位性皮膚炎患者的差異 62
4.2.3 正常人與心臟疾病患者的差異 73
第五章 實驗總結與未來展望 83
參考文獻 85

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