用傳統的高能量乳化方法製備藥物通常會導致藥物變質。我們利用眾所周知的Diet Coke-Mentos反應（DCMR），提出了一款U型管反應器，該反應器可以產生氣泡流用於低能量乳化平台。 U型管反應器中的液體是用液態CO2鋼瓶加壓而成的氣體過飽和溶液，作為Diet Coke。當作為Mentos的粗糙玻璃珠通過U型管反應器的左管壁進入碳酸水中時，會自發性產生劇烈的氣泡流，在右管臂的油水界面處介導有效的乳化作用，形成不同類型的乳液。由DCMR系統衍生的氣泡流，在擾動的過程中不會有明顯的溫度上升，從而保障了乳化藥物的活性。實驗結果表明，由DCMR介導的氣泡流可提供一個通用的平台，用於生產O/W或W/O乳化粒子作為藥物的載體。這種新的乳化平台可以成為一種有吸引力的方法，以小規模定制的方式配製各種藥物輸送系統，以滿足每個人對個人化藥物的需求。

Formulation with high-energy emulsification methods often causes the drug deterioration. Taking advantage of the well-known Diet Coke–Mentos reaction (DCMR), a U-shaped tube reactor that can produce an eruption of bubbly flow that can serve as a low-energy emulsification platform, is proposed. The liquid in the U-tube reactor is a supersaturated solution of aqueous CO2, functioning as the Diet Coke. When glass beads with rough surfaces, serving as the Mentos, are dropped into the carbonated water through the left arm of the U-tube reactor, an eruptive bubbly flow is spontaneously created, mediating an effective emulsification at a compound water–oil interface in the right arm to form different types of emulsions. This DCMR-derived bubbly flow is accomplished without producing significant temperature elevation, thereby safeguarding the activity of the drug to be emulsified. Experimental results demonstrate that the DCMR-mediated bubbly flow may provide a versatile platform for the production of O/W or W/O droplets as drug carriers. This new emulsification platform can be an attractive approach in formulating a variety of drug delivery systems in a small-scale customized manner to fit the needs of each individual for personalized medicine.

摘要...............................Ⅰ
Abstract...........................Ⅱ
Table of Content.….................Ⅲ
List of Figures....................Ⅳ
Chapter 1 Introduction.............1
Chapter 2 Materials and Methods…...3
Chapter 3 Results and Discussion...6
References.........................13

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