隨著老年化的趨勢以及越來越進步的技術與觀念等的影響下，傳統敷料所能提供的效用已經達不到需求，隨之而來的各種先進敷料在近年來開始蓬勃發展，創新傷口敷料將朝著使照護省時、省力、經濟、有效為原則來發展。因此本研究開發了一種新型傷口敷料，希望藉由平時人體運動即能產生電輸出，進一步進行電化學反應產生活性氧物質，再經由活性氧物質和細菌表面作用使之失去活性死亡而達到殺菌的作用。除了藉由平時人體的運動外，我們在敷料中加入了一熱電觸媒「碲化鉍」，即使是待在室內無法運動的狀態下，也能藉由外界的溫度差產生活性氧物質達到殺菌的效果。本研究結果顯示，此種動靜皆可使用的敷料具有極大的潛力在未來可以成為另一種新型敷料的選擇。

With the increasing aging population and the high probability of bacterial infection, the demand for more advanced wound dressing technologies is rapidly increasing. Recently, the wound dressing market have approached towards developing innovative dressings which are more efficient, cost-effective and easy to use. Therefore, in this work, we have designed a novel kind of dressing which can be triggered by the various external stimuli like the human motion and temperature gradients. The triboelectric nanogenerator (TENGs) was employed to harvest the energy from the mechanical movement which was used to trigger the electrochemical reaction in the dressing to generate ROS that can cause oxidative damage to kill the bacteria present in the wound. In addition, the thermal catalyst bismuth telluride (Bi2Te3) was integrated with the dressing which can be stimulated by a temperature gradient to generate ROS. The as-developed the wound dressing provides a great potential to be a kind of advanced dressings in the future which can get triggered by both static and dynamic effect to generate ROS to prevent bacterial infections at the wound site.

摘要 I
Abstract II
List of Figures V
Chapter 1 Introduction 1
Chapter 2 Literature Review and Theory 3
2.1 Triboelectric Nanogenerator 3
2.1.1 Triboelectric Effect 3
2.1.2 Mechanism of Triboelectric Nanogenerator 5
2.1.3 Development of Triboelectric Nanogenerator 8
2.2 Source of Catalysis 9
2.2.1 Photocatalyst 9
2.2.2 Piezocatalyst 11
2.2.2 Thermalcatalyst 12
2.3 Reactive Oxygen Species (ROS) 13
Chapter 3 Experimental Section 15
3.1 Material and Reagent 15
3.2 Instrument 17
3.3 Fabrication of Wearable Triboelectric Nanogenerator 18
3.4 Fabrication of Wound Dressing 18
3.4.1 Preparation of Chitosan hydrogel 18
3.4.2 The Synthesis of Bi2Te3 19
3.4.3 Preparation of Wound Dressing 20
3.5 Characterization 20
3.6 Bacteria Culture 21
3.6.1 Growth of bacterial strains 21
3.6.2 Preparation of Agar Plate 22
3.6.3 Disinfection Performance 23
3.7 Detection of H2O2 24
3.8 In Vitro Cell Toxicity 25
3.8.1 Cell Culture 25
3.8.2 Cytotoxicity 25
Chapter 4 Result and Discussion 27
4.1 Characterization of Wound Dressing 27
4.1.1 Structure of Wound Dressing 27
4.1.2 Application in Disinfection by Bi2Te3 30
4.2 Characterization of TENG 33
4.2.1 Mechanism 38
4.3 Cell toxicity 43
4.4 Application in Real Model 46
Chapter 5 Conclusion 48
Reference 49
Publication 53
Conference 53

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