帳號:guest(18.118.166.51)          離開系統
字體大小: 字級放大   字級縮小   預設字形  

詳目顯示

以作者查詢圖書館館藏以作者查詢臺灣博碩士論文系統以作者查詢全國書目
作者(中文):歐柏瑞
作者(外文):Oscar, Brian-David
論文名稱(中文):台灣能否能提升其在基因測序價值鏈之地位:體學生物科技公司之案例研究
論文名稱(外文):Can Taiwan Move Up The Value Chain in Gene Sequencing?: Lessons from Taiwan’s Personal Genomics, Inc.
指導教授(中文):謝英哲
指導教授(外文):Hsieh, Ying-Che
口試委員(中文):林士平
翁晶晶
謝英哲
口試委員(外文):Lin, Sirirat-Sae
Weng, Jing-Jing
Hsieh, Ying-Che
學位類別:碩士
校院名稱:國立清華大學
系所名稱:國際專業管理碩士班
學號:104077431
出版年(民國):106
畢業學年度:105
語文別:英文
論文頁數:45
中文關鍵詞:體學生物科技股份有限公司,台灣生物科技李鍾熙博士技術擴散
外文關鍵詞:Personal Genomics Inc.TaiwanbiotechDr. Johnsee LeeTechnology Diffusion
相關次數:
  • 推薦推薦:0
  • 點閱點閱:644
  • 評分評分:*****
  • 下載下載:55
  • 收藏收藏:0
摘要

台灣在諸多科技產業上有突兀的表現,然而卻一直無法成功地打入生技產業,而生技產業的前景在台灣也是不被看好的,並且希望政府不要再投入更多資源在生技產業上。所以有些人認為生技產業的發展需要規模經濟,相較之下美國比台灣就更有優勢。其中一個維持大眾信心的手法,就是在本地擁有該領域的專家,而在體學生物科技股份有限公司的李鍾熙博士即是這樣的人物。體學生物科技股份有限公司希望將台灣精湛的半導體產業技術轉移到全球的基因測序市場,讓台灣佔有一席之地。此公司有充沛的私部門資金和業界、學界、工研院與中研院等研究機構有良好的關係。本論文由一零六年五月二十六日與李鍾熙博士的採訪延伸,本文結論指出體學生物科技股份有限公司試圖進入一個既有市場上代表著台灣的一種風險。它代表風險而非不確定性,基因測序必然有一定的市場,且已經由數種技術成功做出,而李博士的權威與產業連結也使公司將成功機會最大化的同時,讓所需耗費的資源降到最低。
After succeeding in many other technologies, Taiwan is having a hard time entering biotech. Critics are tired of the national expenditure. Some claim biotech inherently favors economies of scale, favoring the United States, versus smaller economies like Taiwan. One method to maintain public support is to have star players involved at the national level. Personal Genomics Incorporated’s Dr. Johnsee Lee is such a star. PGI hopes to leverage Taiwan’s prowess in the semiconductor industry into a position in the global gene sequencing market. PGI has private funding as well as good relationships with industry, universities, and government institutions such as ITRI and Academica Sinica. This paper is based on the interview with Johnsee Lee (李鍾熙), CEO of PGI on May 26th, 2017. This paper concludes that Personal Genomics represents a reasonable risk for Taiwan, as it attempts to enter an existing market. This means it represents risk, not uncertainty. There is definitely a market for gene sequencing, and sequencing has already been done successfully with a half a dozen different technologies. Dr. Lee’s prominence and connections should also allow his company to minimize assets needed while maximizing its chances for success.
TABLE OF CONTENTS.
Abstract a
摘要 a
Key words: b
Acknowledgement b
Dedication c
Table of Contents. d
List of Tables. g
List of Figures. g
1. Introduction 1
2. Literature Review 3
2.1.1. Development Literature 3
2.2.1 Moore’s Law 8
2.2.2 Dreams and Dramas of Future Applications of Genomics. 10
2.2.3 Technology Adoption Lifecycle Model. 13
2.2.4 Less Is More: Clayton Christensen-Style Disruption 18
2.2.5 Raymond Vernon’s Product Life-Cycle Theory. 19
2.2.6 The Personal Genomic Product. Small and Inexpensive. 19
3. Taiwan’s Personal Genomics and the Background of Dr. Johnsee Lee (李鍾熙) 25
3.1 The Next Morris Chang Will Be Underfunded. 25
3.2 Selling Biotech Stocks, Canadian Experience, Implications for PGI. 26
3.3 illumina 28
4. A Tale of Two Scientists. 29
4.1 Scientist 1: Yang-Ming’s Dr. Tung. (董建億) 29
4.2 Scientist 2: Dr. Johnsee Lee: Citizen-Scientist, Rock Star. 31
5. Dr. Lee and Personal Genomics. 34
5.1 Respect for IP. 34
5.2 The Challenges of Duplicating illumina’s End-to-End Service 35
5.3 Dr. Lee to Conduct an International Orchestra. 36
6. Conclusion. 39
References. 41

Andersson, T., Gleadle, P., Haslam, C., & Tsitsianis, N. (2010). Bio-pharma: A financialized business model. Critical Perspectives on Accounting, 21(7), 631–641.
Baker, M. (2012). Biorepositories: Building better biobanks. Nature, 486(7401), 141–146.
Beal, G. M., Bohlen, J. M., & others. (1957). The diffusion process. Agricultural Experiment Station, Iowa State College.
Birney, E. (2012). The making of ENCODE: lessons for big-data projects. Nature, 489(7414), 49–51.
Bower, J. L., & Christensen, C. M. (1995). Disruptive technologies: catching the wave. Retrieved from http://www.hbs.edu/faculty/Pages/item.aspx?num=6841
Briscoe, J. L., & Cho, S.-Y. (2011). A periodically coupled plasmon nanostructure for refractive index sensing. Optics Express, 19(9), 8815–8820.
Christensen, C. M., Raynor, M. E., & McDonald, R. (2015). Disruptive innovation. Harvard Business Review, 93(12), 44–53.
Coase, R. H. (1937). The nature of the firm. Economica, 4(16), 386–405.
Complete Genomics. (2017, February 19). In Wikipedia. Retrieved from https://en.wikipedia.org/w/index.php?title=Complete_Genomics&oldid=766348426
Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., … others. (2013). Multiplex genome engineering using CRISPR/Cas systems. Science, 339(6121), 819–823.
Cyranoski, D. (2016). Chinese scientists to pioneer first human CRISPR trial. Nature News, 535(7613), 476.
Dodgson, M., Mathews, J., Kastelle, T., & Hu, M.-C. (2008). The evolving nature of Taiwan’s national innovation system: The case of biotechnology innovation networks. Research Policy, 37(3), 430–445.
Economy of Taiwan. (2017, July 19). In Wikipedia. Retrieved from https://en.wikipedia.org/w/index.php?title=Economy_of_Taiwan&oldid=791354522
Feng, W., Zhao, S., Xue, D., Song, F., Li, Z., Chen, D., … Liu, Y. (2016). Improving alignment accuracy on homopolymer regions for semiconductor-based sequencing technologies. BMC Genomics, 17(7), 521. https://doi.org/10.1186/s12864-016-2894-9
Furman, J. L., Porter, M. E., & Stern, S. (2002). The determinants of national innovative capacity. Research Policy, 31(6), 899–933.
Glenn, T. (2016, March 24). 2016 NGS Field Guide – Table 3a – Purchase costs. Retrieved July 22, 2017, from http://www.molecularecologist.com/next-gen-table-3a-2016/
Hu, M.-C., & Mathews, J. A. (2005). National innovative capacity in East Asia. Research Policy, 34(9), 1322–1349.
Human Genome Project. (2017, July 19). In Wikipedia. Retrieved from https://en.wikipedia.org/w/index.php?title=Human_Genome_Project&oldid=791333101
Humphrey, J., & Schmitz, H. (2000). Governance and upgrading: linking industrial cluster and global value chain research (Vol. 120). Institute of Development Studies Brighton. Retrieved from http://biblioteca.fundacionicbc.edu.ar/images/0/01/Clusters_11-00.pdf
ITRI Overview. (n.d.). Retrieved July 23, 2017, from https://www.itri.org.tw/eng/Content/Messagess/contents.aspx?SiteID=1&MmmID=617731521661672477
Johnson, C. (1982). MITI and the Japanese miracle: the growth of industrial policy: 1925-1975. Stanford University Press.
Knight, F. H. (1921). Risk, uncertainty and profit. New York: Hart, Schaffner and Marx.
Kurzweil, R. (2005). The singularity is near: When humans transcend biology. Penguin.
Liao, J. C. (2016). Developmental States and Business Activism: East Asia’s Trade Dispute Settlement. Springer.
Loman, N. J., Misra, R. V., Dallman, T. J., Constantinidou, C., Gharbia, S. E., Wain, J., & Pallen, M. J. (2012). Performance comparison of benchtop high-throughput sequencing platforms. Nature Biotechnology, 30(5), 434–439. https://doi.org/10.1038/nbt.2198
Long-read genome sequencing used for the first time in a patient. (n.d.). Retrieved July 22, 2017, from https://www.sciencedaily.com/releases/2017/06/170622122003.htm
Mathews, J. A., Hu, M.-C., & Wu, C.-Y. (2011). Fast-follower industrial dynamics: the case of Taiwan’s emergent solar photovoltaic industry. Industry and Innovation, 18(02), 177–202.
Moore’s law. (2017, July 8). In Wikipedia. Retrieved from https://en.wikipedia.org/w/index.php?title=Moore%27s_law&oldid=789665872
Mutyala, R. (2017, April 8). Illumina to Sequence Human Genome for $100 | PeerScientist. Retrieved July 23, 2017, from https://www.peerscientist.com/dna-squencing-giant-illumina-to-sequence-human-genome-for-100/
Niosi, J. (2003). Alliances are not enough explaining rapid growth in biotechnology firms. Research Policy, 32(5), 737–750.
Odagiri, H. (2010). Intellectual property rights, development, and catch up: An international comparative study. Oxford University Press.
Porter, M. E. (2001). The value chain and competitive advantage. Understanding Business: Processes, 50–66.
Reardon, S. (2016). First CRISPR clinical trial gets green light from US panel. Nature, 531.
Riggs, A. D. (1975). X inactivation, differentiation, and DNA methylation. Cytogenetic and Genome Research, 14(1), 9–25.
Robison, K. (n.d.). BGI Launches the BGISEQ-500. Retrieved July 22, 2017, from http://omicsomics.blogspot.com/2015/10/this-weekend-brought-formal-launch-of.html
Spearing, S. M. (2000). Materials issues in microelectromechanical systems (MEMS). Acta Materialia, 48(1), 179–196.
Sutherland, B. (2013, November 18). No Moore? A golden rule of microchips appears to be coming to an end. The Economist. Retrieved from http://www.economist.com/news/21589080-golden-rule-microchips-appears-be-coming-end-no-moore
The 100,000 Genomes Project by numbers. (2017, June 5). Retrieved June 24, 2017, from https://www.genomicsengland.co.uk/the-100000-genomes-project-by-numbers/
The World Factbook — Central Intelligence Agency. (n.d.). Retrieved July 20, 2017, from https://www.cia.gov/library/publications/the-world-factbook/rankorder/2172rank.html
Tian, J., Gong, H., Sheng, N., Zhou, X., Gulari, E., Gao, X., & Church, G. (2004). Accurate multiplex gene synthesis from programmable DNA microchips. Nature, 432(7020), 1050–1054.
Timmons, J. A., Spinelli, S., & Tan, Y. (1994). New venture creation: Entrepreneurship for the 21st century (Vol. 4). Irwin Burr Ridge, IL.
TSMC. (2017). TSMC 2016 Annual Report (Annual Financial Report). Retrieved from http://www.tsmc.com/download/ir/annualReports/2016/english/annual2016e.pdf
Vernon, R. (1966). International investment and international trade in the product cycle. The Quarterly Journal of Economics, 190–207.
Wade, R. (2014). The mystery of US industrial policy: the developmental state in disguise. UNCTAD-ILO Volume Edited by Richard Kozul-Wright and Jose Manuel Salazar-Xirinachs.
Washington Consensus. (2017, July 17). In Wikipedia. Retrieved from https://en.wikipedia.org/w/index.php?title=Washington_Consensus&oldid=790958049
Wong, J. (2011). Betting on biotech: Innovation and the limits of Asia’s developmental state. Cornell University Press.
Yin, R. K. (2013). Case study research: Design and methods. Sage publications.
Zhu, B., Wang, X., & Li, L. (2010). Human gut microbiome: the second genome of human body. Protein & Cell, 1(8), 718–725.

 
 
 
 
第一頁 上一頁 下一頁 最後一頁 top
* *